PFAS-Contaminated Drinking Water and Ulcerative Colitis

Ulcerative colitis affects about 1 million Americans. It is typically diagnosed in young adults, though it can occur at any age. While the exact cause is unknown, it involves a combination of genetic, immune, and environmental factors. Managing UC often requires medications, lifestyle changes, or, in severe cases, surgery. Regular medical care is essential for monitoring and controlling flare-ups.

What Are PFAS?

Per- and polyfluoroalkyl substances (PFAS), commonly called “forever chemicals,” are synthetic compounds used since the 1940s in products like nonstick cookware, water-repellent fabrics, food packaging, and aqueous film-forming foam (AFFF) for firefighting. Their resistance to breaking down leads to persistent environmental contamination, particularly in water sources. PFAS such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are detected in approximately 45 percent of U.S. tap water, accumulating in the body over time and raising health concerns.

How PFAS Contaminate Drinking Water

PFAS enter drinking water through various sources, including industrial discharges, landfill runoff, wastewater treatment plants, and AFFF used in firefighting at military bases and airports. These chemicals spread into groundwater and surface water, contaminating municipal and private well water supplies. The widespread presence of PFAS affects communities across urban and rural areas, exposing millions to low but cumulative levels of these chemicals through their drinking water.

The Link Between PFAS-Contaminated Drinking Water and Ulcerative Colitis

Emerging research suggests that prolonged exposure to PFAS in drinking water may be associated with an increased risk of developing or exacerbating ulcerative colitis, particularly in areas with high contamination levels.

Key Research Findings

• University of Wisconsin–Madison (2024): A study found that PFAS exposure, particularly through contaminated drinking water, was linked to altered gut microbiota and increased intestinal inflammation, potentially contributing to UC risk or worsening symptoms in affected individuals.
• Yale School of Public Health (2023): Research indicated that higher blood levels of PFOS and PFOA, often from drinking water, were associated with immune system dysregulation, which may trigger or aggravate autoimmune conditions like UC.
• C8 Science Panel (2011–2013): Studies of a community exposed to PFOA-contaminated water near a DuPont facility found a probable link between PFAS exposure and UC, with higher rates of the disease among residents with long-term exposure.
• Mechanisms of Harm: PFAS may contribute to UC by disrupting the gut microbiome, promoting inflammation, and altering immune responses. These chemicals can affect intestinal barrier function, potentially leading to chronic inflammation characteristic of UC.
• Public Health Impact: While PFAS are linked to various health outcomes, their role in inflammatory diseases like UC is gaining attention, with studies suggesting that chronic exposure via drinking water may exacerbate or increase susceptibility to the condition.

Although the evidence is still developing, studies consistently point to chronic PFAS exposure as a potential environmental trigger for UC, particularly in genetically predisposed individuals or those in heavily contaminated areas.

Who Is at Risk of Developing Ulcerative Colitis from PFAS Exposure?

• Communities Near Contaminated Sites: Areas near industrial facilities, landfills, or sites where AFFF was used (such as military bases and airports) often have elevated PFAS levels in drinking water.
• General Population: With nearly half of U.S. tap water containing PFAS, chronic low-level exposure through drinking water can accumulate over time.
• High-Risk Groups: Individuals with a family history of UC, other autoimmune conditions, or prolonged exposure to contaminated water may face increased risks.

Growing evidence suggests a link between prolonged PFAS exposure in drinking water and an increased risk of ulcerative colitis or worsening of its symptoms. While more research is needed to fully understand this relationship, the potential for PFAS to disrupt gut health and immune function is a concern, especially in areas with contaminated water supplies. If you’re experiencing UC symptoms or live in a high-risk area, consult a healthcare provider and consider testing your water for PFAS. Staying informed and proactive can help manage your health risks.

PFAS Lawyers

If you have testicular or kidney cancer or ulcerative colitis and were regularly exposed to PFAS in drinking water, you may be entitled to compensation for medical bills, lost wages, loss of consortium, and more. Contact us for a free consultation.